Guest star, William Shatner performs various comedy sketches with the Muppets Tonight gang members.
- At the Juice Bar: Johnny and Sal paint beautiful caricatures.
- Pepe and Seymour's Vacation Jacuzzi: Pepe and Seymour play laser tag
- Tales from the Vet: Dr. Phil Van Neuter tests out his latest creation, the petrification gun to turn everybody into stone statues.
- Musical Stage #: Funky Town (sung and performed by the Muppets Tonight gang members)
- Muppet Labs: Bunsen and Beaker demonstrate the vision machine 600.
- Grand Finale Stage Show #: Wherever You Will Go (sung and performed by the Muppets Tonight gang members)