Guest star, Jennifer Aniston hosts a disco dance party with the Muppets Tonight gang members.
- Pigs in Space: Miss Piggy, Link Hogthrob and Dr. Julius Strangepork identify a fossilized fish skeleton.
- Pepe and Seymour 's Vacation Jacuzzi: Pepe and Seymour try to catch a beach ball that ends up in the swimming pool.
- Tales from the Vet: Dr. Phil Van Neuter tests out his latest creation, the Slumber-Tronic 9000.
- Musical #: Wherever you Will Go (sung and performed by Gonzo and the rest of the Muppets Tonight gang members)
- Muppet Labs: Bunsen and Beaker demonstrate the Body Switcher 300.
- Grand Finale Stage #: Gonzo's Magic Act: Gonzo and Jennifer Aniston make Rizzo disappear.